About 40 percent of the affected patients with Huntington's disease—a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase—an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington's disease, according to a pre-clinical study in which the UB experts Sílvia Ginés, Verónica Brito, Albert Giralt and Jordi Alberch, from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences of the University of Barcelona (UBNeuro) have taken part.
* This article was originally published here
